Daniel-Kofi Kyereh has been handed a start by head coach Milovan Rajevac in the Black Stars crucial game against Gabon tonight.
Kyereh, a substitute in Ghana’s 1-0 loss to Morocco last Monday, replaces Joseph Paintsil in the starting lineup.
It is the only change from the loss to the Atlas Lions, with captain Andre Ayew recovering from illness and the head injury he suffered in the previous match to keep his place in the starting lineup.
Thomas Partey and Jordan Ayew both start as well, with Kamaldeen Sulemana keeping his spot on the left wing.
The backline of Andy Yiadom, Daniel Amartey, Alex Djiku and Baba Rahman remains intact.
A win would take Gabon through to the next round of the competition, while the Black Stars also need to avoid defeat in order to keep their hopes of winning a fifth AFCON alive.
The match kicks off at 19:00 GMT (7pm Ghana).